Oltipraz pretreatment could significantly weaken effects of TGF-β1 on TRAP-1 protein in HFLS (p<0.01, vs. TGF-β1-induction group), while the effects of oltipraz was significantly reversed by Lv-TRAP-1 infection (p<0.01, vs. oltipraz pretreatment + TGF-β1 induction group).The protein detection results also showed that oltipraz pretreatment could effectively reverse the TGF-β1 caused decrease of Nrf2 protein intranuclear aggregation in HFLS (p<0.01, vs. cell group; p<0.01, vs. TGF-β1 induction group). Here, TGFB1 is linked to infection.