Tumor cells are absorbed by dendritic cells and macrophages, and tumor DNA may enter the cytoplasm from the phagosomes of antigen-presenting cells to activate the cGAS-STING pathway.Activation of cGAS by cancer cell DNA leads to the production of type I IFNs and chemokines, as well as the upregulation of co-stimulatory molecules such as CD80 and CD86, which jointly stimulate the proliferation and recruitment of tumor-specific T cells into the tumor,thus enhancing the anti-tumor immune response (124). This evidence concerns the gene STING1 and cancer.