In addition, SARS-CoV-2 viral proteins such as viral spike (S) glycoprotein (34), SARS-CoV open reading frame-8b (ORF8b) (35), the transmembrane pore-forming viral Viroporin 3a (also known as SARS-COV 3a) (36) and the viral N protein (37) were shown to activate the NLRP3 inflammasome, thus revealing that NLRP3 inflammasome is potentially an interesting molecular target for the treatment of COVID-19. This evidence concerns the gene NLRP3 and COVID-19.