The pharmacological inhibition of caspase-1 using YVAD inhibitor in Caco-2 (Figures 4A, C) and ACE2-A549 (Figures 4B, D) cells reduced SARS-CoV-2 infection, as revealed by the frequency of spike (S)-positive cells at 24 hours after infection (Figures 4A-D), without affecting cellular viability (Supplementary Figures 3A, B). Here, ACE2 is linked to infection.