Interestingly, we found that NLRP3 expression level increased 24 hours after SARS-CoV-2 infection in phorbol-12-myristate-13-acetate (PMA) - differentiated human THP1 macrophages with different multiplicities of infection (MOI) (Figure 2A, Supplementary Figure 1A) or at different time points after infection with a MOI of 0.2 (Figure 2B, Supplementary Figure 1B). This evidence concerns the gene NLRP3 and infection.