Since MTF-1 plays a crucial role in defense against several cell stress conditions, including oxidative stress and hypoxia, and has been effective in Drosophila models of PD and AD (Saini et al., 2011), making it clear if MTF-1 gene expression modulates the course of human neurodegenerative disorders, including AD, helps shed more light on the molecular mechanisms of AD pathogenesis. The gene discussed is MTF1; the disease is Alzheimer disease.