Hypersensitivity is defined by the World Allergy Organization's Nomenclature Review Committee as “objectively reproducible symptoms or signs initiated by exposure to a defined stimulus at a dose tolerated by normal persons” and allergy as “a hypersensitivity reaction initiated by specific immunologic mechanisms”, which can be divided into IgE-mediated allergy (Type I) or non-IgE-mediated allergy (Types II, III, and IV in Gell-Coombs's classification).11 Here, IGHE is linked to allergic disease.