We could think of 3 possible explanations: (a) after being diagnosed with HAE, the patients can get adequate therapy for their C1-INH-HAE symptoms, thus reducing stress levels, which leads to a more balanced lifestyle with less severe hypersensitivity symptoms; (b) after the diagnosis of C1-INH-HAE, the patients are referred to an allergologist-immunologist, who, aside from treating their HAE, can provide them with treatment for their hypersensitivity as well; and (c) prior to the diagnosis of C1-INH-HAE, edematous symptoms might have been misdiagnosed as allergy. The gene discussed is SERPING1; the disease is Allergy.