The relatively high levels of IL-1β in Rongchang pigs from 2 to 10 days after HuN4 infection might contribute to the persistent increase in body temperature from 2 to 12 dpi and acute lung injury in HuN4-infected Rongchang pigs (Amarilla et al., 2015; Liang et al., 2016). The gene discussed is IL1B; the disease is infection.