Moreover, AG decreased the expressions of p-p38, p-Erk, p-JNK, and p-NF-κB, suggesting that suppressing the HO-1/MAPK and P13K/Akt signaling pathways might be an approach of AG for inhibiting neuroinflammation during AD (Kim et al., 2022). This evidence concerns the gene AKT1 and Alzheimer disease.