Interestingly, the effect of AG in augmenting the level of HO-1 was abolished in Nrf2 knocked-down BEAS-2B cells (Zheng et al., 2019), suggesting that the protective activity of AG against ALI might be partially ascribed to its capacity to regulate Nrf2/HO-1 signaling pathway-mediated inflammation. Here, HMOX1 is linked to acute respiratory distress syndrome.