Altogether, these findings reveal that modulating the HO-1/MAPK, P13K/Akt, SIRT1- NLRP3, and Notch/HES-1-NF-κB signaling pathways might be the mechanism of AG in mitigating neuroinflammation, cognitive impairment, depression, and AD. The gene discussed is NLRP3; the disease is depressive disorder.