In conclusion, this study demonstrated that LWD effectively improved the learning and memory ability of AD mice, and the mechanism of LWD may be related to the activation of the autophagy pathway regulated by the PI3K/Akt signaling pathway, the attenuation of glial cell activation-induced inflammatory response and the upregulation of the expression of Beclin1 and LC3B. Here, MAP1LC3B is linked to Alzheimer disease.