The first 20 pathways were identified, many of which were closely related to AD, and the relevant targets in LWD were mainly concentrated in PI3K-Akt pathway, cellular aging pathway, inflammatory pathway, MAPK pathway and Alzheimer’s disease-related pathway, among which PI3K-related pathway enriched with relevant targets as many as 38 (Figure 1D). The gene discussed is AKT1; the disease is early-onset autosomal dominant Alzheimer disease.