Tetsuro Taki et al. demonstrated the biological significance of regulating the TGF-β signal in the cancer cell matrix through the correlation verification of CD109 and LTBP1, and they indicated that the expression level of CD109 plays an important role in promoting the proliferation and diffusion of LUAD cells (Taki et al., 2020). The gene discussed is TGFB1; the disease is cancer.