REST and epilepsy: •BRAFV600E mutations in neural progenitor cells during development lead to:epileptic seizures, which are often associated with GG and PXAneuronal abnormalities, increased numbers of astro- and oligodendroglia•BRAFV600E-induced epileptogenesis is mediated by RE1-silencing transcription factor (REST), a regulator of ion channels and neurotransmitter receptors associated with epilepsy