•1-hit model: BRAFV600E alone induces tumor formation with oligodendroglial andPLNTY-like features; positive immunoreactivity for MAP2, Olig2 and CD34•2-hit model: BRAFV600E and Akt activation leads to neoplastic tumor growth, exhibit substantial neuronal activity and epileptogenic propensity; a glioneuronal phenotype immunoreactive for MAP2, GFAP, NeuN and Olig2; tumors that recapitulate GG-like features•3-hit model: BRAFV600E/pAkt/Trp53-loss tumors exhibit glioneuronal clonality with aGG-like features. The gene discussed is RBFOX3; the disease is neoplasm.