•No evidence of tumor formation in the brain of hGFAP-cre;BRAFV600Efl/+ mice.•These mice with BRAF activation alone survived until 3 wks. of age•Orthotopic injection of hGFAP-cre;BRAFV600Efl/+ cells or Olig2-cre;BRAFV600Efl/+ cells into SCID mice do not induce tumor formation. The gene discussed is HGFAC; the disease is neoplasm.