analyzed mutations in only one case of admixed neuroendocrine carcinoma and endometrioid adenocarcinoma, focusing on genetic alterations in mutational hotspots of 50 cancer-related genes and reporting the existence of mutations in PTEN, PIK3CA, FGFR3, and CTNNB1 (26). This evidence concerns the gene PIK3CA and neuroendocrine carcinoma.