These third-generation TKIs exhibit an enhanced ability to penetrate the blood-brain barrier (BBB), opening up new avenues for managing this challenging condition.<h4>Case summary</h4>We report the case of a 48-year-old Chinese man diagnosed with advanced NSCLC harboring an epidermal growth factor receptor (<i>EGFR</i>) mutation. This evidence concerns the gene EGFR and non-small cell lung carcinoma.