IDH1 and neoplasm: Similarly, patient 58, a 56-year-old woman with IDH-mutant-codel tumor, had a TP53:p.R248W mutation with gradually increasing VAF (from 0.3% to 0.7%) detected in three sequential cf-tDNA samples over 10.5 months, and the MRI changes were observed until 6.8 months later (Figure 4K).