Based on our results, we observed several clinically relevant points: (1) Hp fucosylation is significantly higher in both early- and late-stage HCC compared with controls, which agrees with previous reports using lectin- or mass spectrometry-based methods showing high fucosylation of Hp not only in HCC, but also in other cancers (23, 28, 44, 45). This evidence concerns the gene HP and hepatocellular carcinoma.