To locate the most significant genes from the identified GO terms, we filtered the genes with a PBS selection index < 0.01, and minimized myopia association P-values yielded three loci: MED1, ARL6, and RPGRIP1L. The most significant SNPs in ARL6 and RPGRIP1L were enriched in PBS to close to zero (Fig. 2), indicating that allele frequency shifts in these two genes are less likely to be associated with myopia. The gene discussed is ARL6; the disease is myopia.