APOE and metabolic dysfunction-associated steatotic liver disease: For example, hyperoside, a predominant flavonoid in nelumbinis folium, has been shown to effectively lower cholesterol and triglyceride levels in rats with non-alcoholic fatty liver disease (NAFLD) via cholesterol metabolism pathways, such as amino acid N-acyltransferase 2 (Acnat2) and Apolipoprotein E (ApoE) [15].