MGMT and glioblastoma: For IDHwt GBM, mean MGMT scores above and below the TERT VAF cutoff of 0.18 (identified by multi-part linear regression) were 14.06% (in the “methylated” range) and 9.56% (in the “unmethylated” range), respectively (p = 0.105 via unpaired student’s t-test, Fig. 2H).