Based on subset analyses, this paradoxical interval between VAFs 0.10–0.17 was driven by IDHwt GBMs, as GBM samples with low TERT promoter VAFs were at least as likely to be MGMT promoter methylation-positive as those with higher VAFs (Fig. 3 C-D, Supplementary Figure S4B). Here, MGMT is linked to glioblastoma.