SLC7A11 and adrenal cortex carcinoma: If attempting to target the metabolic vulnerability displayed by ACC cells with high expression of SLC7A11, such as inhibiting glucose transporters which would impede glucose uptake and subsequently lead to a significant reduction in NADPH production through the phosphogluconate pathway, it is very likely to induce the accumulation of intracellular disulfide bonds and disulfides, thereby triggering disulfidptosis.