So far, multiple cancer‐related signaling pathways were shown to be activated in response to changes in CD24 expression, directly or indirectly, including Wnt/β-catenin [64, 65], Mitogen activated kinase (MAPK) [66], Src or PI3K/Akt kinase [67], as well as Notch and Hedgehog pathway [68, 69], which have been analyzed in various types of cancers (Fig. 2), as described below. The gene discussed is AKT1; the disease is cancer.