Using immunohistochemical analysis, Wan et al. also found that Notch1 expression positively correlated with CD24 expression in hepatocellular carcinoma cells (HCC) and adjacent samples, and the interactions between CD24 and the Notch1-related signaling pathways might constitute a potential regulation mechanism that is involved in HCC pathogenesis [87]. Here, NOTCH1 is linked to hepatocellular carcinoma.