NUAK1 and familial pancreatic carcinoma: The pro-metastatic function of NUAK1 was first uncovered in pancreatic cancer and colon cancer, which was supported by the observation that ectopic overexpression of NUAK1 in human pancreatic cancer cell line PANC-1 and human colon cancer cell line DLD-1 induced a dramatic increase in migration and invasion activity in vitro and metastasis in vivo [14].