After analyzing transcriptome data of oral cancer patients from TCGA database, we found that PFKFB1 expression was lower in the tumor tissues than in the tumor-adjacent normal tissues (p = 0.001, Table 1, Fig. 1A), but PFKFB2 expression did not differ significantly (p = 0.322; Table 1, Fig. 1B). The gene discussed is PFKFB1; the disease is lip and oral cavity carcinoma.