PFKFB3 and melanoma: PFKFB3 expression has been induced during the G1/S transition [44]. The 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (a kind of PFKFB3 inhibitor) can induce G0/G1 arrest in A375 human melanoma cells [44] and G2/M arrest in Jurkat cells [45].