According to above findings, PFKFB3 and PFKFB4 could contribute to many facets of oral cancer progression including controlling cell cycle progression, metastasis, and chemoresistance, which might not only act as regulators of glucose metabolism, but also act in a non-glycolysis-dependent manner (such as cell cycle regulation, autophagy, and transcriptional regulation) in OSCC [67]. Here, PFKFB4 is linked to lip and oral cavity carcinoma.