The overexpression of PFKFB4 was found in breast cancer [19], triple-negative breast cancer (TNBC) [20], osteosarcoma [21], cervical cancer [22], clear-cell renal cell carcinoma [23], melanoma[24], HCC [18], glioblastoma [25], bladder cancer [26], gastric cancer [27], pancreatic cancer [28], and prostate cancer [29]. This evidence concerns the gene PFKFB4 and Familial prostate cancer.