PFKFB3 and lip and oral cavity carcinoma: To investigate if PFKFB3 and PFKFB4 play role in cell viability of oral cancer cells, OSCC cells were knocked down using siRNA against PFKFB3 or PFKFB4. After knockdown, the gene (Fig. 3A) and protein (Fig. 3B) levels of PFKFB3 or PFKFB4 were decreased.