PFKFB4 and metastatic malignant neoplasm in the lymph nodes: Moreover, high PFKFB4 expression was associated with a short PFI in patients with lymph node metastasis [N1, N2, and N3, AHR = 2.00, p = 0.009, Table 4; p = 0.003, Fig. 2G] and late pathological stages [III and IV; AHR = 1.63, p = 0.03, Table 4; p = 0.025, Fig. 2H].