Interestingly, the combination of a low dose of a selective p38 inhibitor, losmapimod (GW856553), with dexamethasone has been shown to have a synergistic effect on the suppression of CXCL8 release from peripheral blood mononuclear cells (PBMCs) of COPD patients [42] (Table 1 and Fig. 3). The gene discussed is CXCL8; the disease is chronic obstructive pulmonary disease.