Theoretically, DOX mainly plays the following roles to suppress tumor: (1) It directly kill tumor cells; (2) The dead tumor cells release an “eat me” signal, such as CRT, to help DCs phagocytize apoptotic cells and present tumor antigens; (3) DOX trigger tumor DNA damage, and the DNA fragments activate the cGAS/STING/IFN-I pathway, thus promoting antitumor immunity. Here, CGAS is linked to neoplasm.