(4) As foreign antigens, lysed OK-432 recruited and matured the most potent antigen presenting cells, or DCs, into the tumor tissues, which provided the foundation for further antitumor immunity; (5) The thermal ablation and DOX that induced the cell death both promoted the tumor-antigen-presentation of DCs; (6) Self-DNA fragments derived from OK-432 lysates and tumoral DNA resulting from DOX killing both activated the cGAS/STING/IFN-I pathway in DCs. Here, CGAS is linked to neoplasm.