The synergistic effect of ROD hydrogel treatment recruited more imDCs, promoted their maturation in tumor tissue, activated the intracellular cGAS/STING/IFN-I signaling pathway, enhanced the cytotoxicity of CD8+ T cells, increased the proportion of M1-TAMs, reduced the percentage of MDSCs and Treg cells, and finally improved the therapeutic efficacy. This evidence concerns the gene STING1 and neoplasm.