We found serum sclerostin levels significantly higher in males than females in the T2D group (45.99 (32.05–55.36) pmol/L vs. 36.64 (26.88–43.02) pmol/L, p = 0.002) and healthy controls (35.65 (27.62–47.35) pmol/L vs. 29.08 (21.51–34.82) pmol/L, p < 0.001). Here, SOST is linked to type 2 diabetes mellitus.