Immunofluorescence analysis revealed significantly increased sclerostin expression in T2D patients’ vessels compared to control subject’ vessels (24.4 ± 6.4 vs. 7.5 ± 2.8, p = 0.022) without significant differences in the total cell nuclei count between groups (p = 0.496) (Fig. 4E). Here, SOST is linked to type 2 diabetes mellitus.