Finally, CRS (odds ratio (OR) = 13.618, 95% confidence interval (CI) 1.499–123.709; P = 0.013) and baseline ALB (OR = 0.854, 95% CI 0.754–0.967; P = 0.020) were identified as the independent factors associated with post-CAR-T hypoalbuminemia. This evidence concerns the gene ALB and Hypoalbuminemia.