In our scRNAseq data of CD34 + CML cells, both PRTN3 and ELANE were significantly upregulated in CML cells with high BCR-ABL1 score (median pooled PR1 score 0.25 vs 0.11, log2FC = 1.184, P = 5.6 × 10−6, two-sided Mann-Whitney test, Fig. 5a). Here, CD34 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.