One of the interestingly behaving cell type was the largest CD8 + T cell population CD8 + TEM/EMRA, whose levels were higher in CML diagnosis compared to healthy controls and other cancers (CD8 + TEM/EMRA median 20.157% vs 5.495%, log2FC = 1.875, P = 0.0082, Padj = 0.0662), but their levels decreased following TKI initiation (CD8 + TEM/EMRA median 20.157% vs 5.623%, log2FC = 1.842, P = 0.009, Padj = 0.133, Fig. 1d, e, Supplementary Fig. 4b). The gene discussed is CD8A; the disease is cancer.