The most significantly expanded immune subsets in patients with CML (n = 10) in comparison to healthy (n = 7) included different NK cell populations, such as the most prevalent mature CD16 + NK cells (median out of all CD45 + 18.420% vs. 9.303%, log2 fold-change of medians [log2FC] = 0.986, Padj = 0.00967, Benjamini-Hochberg corrected two-sided Mann-Whitney test), immature CD16- (median 0.92% vs 0.300%, log2FC = 1.620, Padj = 0.00614), and NK cells not specified by Celltypist (median 3.625% vs 0.774%, log2FC = 2.228, Padj = 0.00017, Fig. 1d–e). Here, FCGR3A is linked to chronic myelogenous leukemia, BCR-ABL1 positive.