The most common inhibitory interactions between NK and CD34 + CML cells included LGALS9 – TIM3 and PVR and TIGIT, and the inhibitory ligands LGALS9 and PVR were expressed in both BCR-ABL1 low and high-expressing CD34+ cells. The gene discussed is TIGIT; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.