MAPT and Mental deterioration: Given that p-tau wreaks havoc on cultured cells in a timeframe seemingly too short to form the canonical fibrils that constitute neurofibrillary tangles (Figure 2, and see [30]), and that tangles and cognitive decline are in large separable in animal models (e.g., [29, 108, 109]), we argue that measures curbing the cytotoxicity, instead of fibrillogenesis, of tau is a more viable approach to drug development.