However, tumor growth in Ahr–/– mice did not affect MEP differentiation relative to that in wild-type (WT) mice, as evidenced by the consistent number of peripheral RBCs and PLTs (Fig. 2c and Extended Data Fig. 2c) and BM MkPs and EryPs (Fig. 2d and Extended Data Fig. 2d), suggesting that AhR regulates MEP differentiation into megakaryocytes in tumor-bearing mice. The gene discussed is AHR; the disease is neoplasm.