S100A8/S100A9 has been linked to chronic TLR4/RAGE signaling and chronic expression of IL-1b, IL-6 and tumor necrosis factor in long COVID/Postacute sequelae of SARS-CoV-2 infection (PASC)44, potentially explaining the elevated IL-6 expression in WTM and OM plasma. This evidence concerns the gene TLR4 and long COVID-19.