We define four distinct tumor-specific subtypes: T1(PD-L1-CD3-CD8-), T2(PD-L1+CD3+CD8+), T3, and T4(PD-L1+), and four stroma-specific subtypes: S1, S2(PD-L1-CD3-CD8-), S3, and S4(PD-L1+CD3+CD8+). The gene discussed is CD8A; the disease is neoplasm.