It must be borne in mind that previous studies in Drosophila and silkworm demonstrated that during the developmental stages and metamorphosis further to pathogenic infections 20-hydroxyecdysone (20E), one of the two most important developmental hormones, improves the insect innate immune response, via upregulation of the PGRP-LCs45,46. This evidence concerns the gene PGLYRP1 and infection.