TF and neoplasm: For example, micelles are suitable for the delivery of water-insoluble and amphiphilic drugs, and liposomes can increase the cellular uptake of a variety of drugs.14,15 2) Smart nanoparticles based on specific materials and components of nanocarriers can respond to external and internal stimuli, such as enzyme, pH, temperature, as well as optical and magnetic regulation, etc. 3) Another embodiment of smart nanoparticles is their tumor targeting characteristics by functionalizing their surface with tumor-specific ligands (such as antibodies, peptides, aptamer, and transferrin, etc.).