Induced REST targets included genes that may contribute to AD pathogenesis, such as the tau kinases cyclin-dependent kinase (dk5) and glycogen synthase kinase 3β (Gsk3b), and proapoptotic genes including Daxx, Foxo3, Gadd45a and Casp9 (Fig. 4d and Supplementary Data 5). This evidence concerns the gene REST and Alzheimer disease.