Induced REST targets included genes that may contribute to AD pathogenesis, such as the tau kinases cyclin-dependent kinase (dk5) and glycogen synthase kinase 3β (Gsk3b), and proapoptotic genes including Daxx, Foxo3, Gadd45a and Casp9 (Fig. 4d and Supplementary Data 5). The gene discussed is FOXO3; the disease is Alzheimer disease.