PSP is a primary tauopathy characterized by the overexpression of 4-repeat tau isoform in both neuronal and glial cells, leading to cell-specific tau lesions including neurofibrillary tangles (NFT) in the neurons, tufted astrocytes (TA), coiled bodies (CB) in oligodendrocytes, and tau threads (TauTh) in white matter. Here, MAPT is linked to tauopathy.