PSP is a primary tauopathy characterized by the overexpression of 4-repeat tau isoform in both neuronal and glial cells, leading to cell-specific tau lesions including neurofibrillary tangles (NFT) in the neurons, tufted astrocytes (TA), coiled bodies (CB) in oligodendrocytes, and tau threads (TauTh) in white matter. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.