Consistent with the results that DDR2, KANK2, and STOM are all upregulated in human PSP and rTg4510 mouse brain transcriptome, our initial tau Drosophila screening experiment (Fig. 4c) demonstrated that RNAi inhibition of these genes suppressed tau-mediated cell toxicity in this model. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.