Notably, treating the co-culture system with 100 nM BAY-876 caused significant suppression of 4T1 cells while expanding the immune cell populations associated with the adaptive antitumor immunity including DCs, M1 macrophages, CD4+ T cells and CD8+ T cells, on account of the capacity of BAY-876 to selectively inhibit GLUT1 to block tumor cell-intrinsic glucose uptake. Here, SLC2A1 is linked to neoplasm.