FOXP3 and neoplasm: As a resultant of the BAY-876-induced high glucose TME, flow cytometric analysis on the extracted tumors showed that the immunosuppressive phenotype (Foxp3 and IL−10) of Tregs has decreased by 23.92% and 13.4% in the DNA-PAE@BAY-876 group compared with the control group (Fig. 8a, b), while the tumor infiltration of IFN-γ+/CD8+ T cells has increased by 30.33% (Fig. 8c, d).