SCN8A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: MV1312 shows five to sixfold sensitivity for Nav1.6 over Nav1.1, and has been shown to rescue seizure behavior in a zebrafish model of Dravet syndrome where a loss-of-function Nav1.1 function results in overexpression of Nav1.6 and epileptogenesis (Weuring et al, 2020).