Furthermore, unlike conventional promoters, the majority of the CpG islands in the TERT promoter region are hypermethylated in cancer (Dessain et al. 2000; Renaud et al. 2007; Stern et al. 2017) except for a small nonmethylated region upstream of the transcriptional start site (TSS), which coincides with the TPMs. The gene discussed is TERT; the disease is cancer.