TERT and cancer: Given the nonconventional DNA methylation pattern at the TERT locus with hypermethylation around the TPM sites in cancer cells and hypomethylation in noncancerous primary cells (Dessain et al. 2000; Renaud et al. 2007; Stern et al. 2017), we next tested whether the DNA methylation pattern is altered between cell lines with different TPM status.