By studying the protein interaction, our results verified that six genes with high gene expression were closely associated as a set of unified genes with systemic expression, specifically COL1A1, COL1A2, COL6A3, COL4A1, COL3A1, and PDGFRB. The high expression of these genes presented and contrasted clearly in the heat map analysis of tumor tissue in Figure 4. Here, COL3A1 is linked to neoplasm.