According to our study findings, at the same level of gene expression analysis, patients diagnosed with HNSCC showed no significant differences in cancer grade for the genes PDGFRB, TEAD2, COL1A2, RCN1, OSBPL10, and CHCHD10. The P-value analysis, set at a significance level of P<0.05, indicated that these genes had comparable cancer grades among the HNSCC patients. This evidence concerns the gene TEAD2 and head and neck squamous cell carcinoma.