PLG and variant Creutzfeldt-Jakob disease: Other diagnostic assays tested may include “plasminogen-bead capture PMCA”, which was previously shown to detect blood samples from vCJD patients with high levels of sensitivity and specificity, including a small number of preclinical samples [34], and the “direct detection assay” (DDA), an ELISA-style immunoassay that captures PrPSc on stainless steel particles, which has also been shown to detect endogenous vCJD in patient blood samples [65].