This region also plays the role of a core promoter crucial for the transcriptional upregulation of hST8Sia I in Fas-induced Jurkat T cells [13], human melanoma SK-MEL-2 cells [14], valproic acid-induced SK-N-BE(2)-C human neuroblastoma cells [15], cordycepin-induced SK-N-BE(2)-C human neuroblastoma cells [16], and curcumin-induced A549 human lung cancer cells [17]. The gene discussed is FAS; the disease is melanoma.