MAPT and early-onset autosomal dominant Alzheimer disease: Abnormal U1 snRNAs have been detected in patients’ brains with Alzheimer’s disease [53], and Tau can bind to the protein components of U1 snRNP in Drosophila leading to splicing disorder and neuronal degeneration [54], suggesting that U1 snRNP may be a potential pathogenesis and target of Alzheimer’s disease [55].