YAP1, encoding the key component of Hippo pathway, was activated prevalent in various cancers including oral squamous cell carcinoma, cervical squamous cell carcinoma and hepatocellular carcinoma and coupled with extensive oncogenic characteristics and processes such as KRAS mutation, cancer stem cell maintaining, EMT promotion, tumor immune evasion [25]. The gene discussed is KRAS; the disease is hepatocellular carcinoma.