CAL protein-coding associated gene-set mutations correlated with increased level of focal adhesion components regulating cell migration, MAPK cascade and TNF signaling pathways, and with decreased DNA repair and corresponding apoptotic process in UCEC; with increased hippo signaling pathway and regulation of IL-8 production, and with decreased MAPK signaling pathway and key components regulating angiogenesis in COAD; and with increased protein kinase B signaling and decreased MAPK/PI3K-Akt cascade in BRCA (Fig 6A and 6B). This evidence concerns the gene TNF and colon adenocarcinoma.