On the other hand, overexpression of miR125a resulted in a decline in ICAM-1 and VCAM-1 expression in human brain microvessel endothelial cells [42], and our result showed that miR125a positively correlated with markers of endothelial dysfunction (i.e. ICAM-1 and VCAM-1). The gene discussed is ICAM1; the disease is endothelial dysfunction.