The T-cell changes caused by inhibiting ACC1 reduce disease severity in murine models of listeria infection, chronic graft-versus-host disease, multiple sclerosis (Lee et al., 2014), and T cell-mediated asthma (Nakajima et al., 2021); it also promotes resistance to parasites (Endo et al., 2019). The gene discussed is ACACA; the disease is asthma.