CD4 and asthma: When the Cd4-Cre::Acc1fl/fl and Acc1fl/fl control mice were induced to undergo OVA-mediated asthma, we indeed observed that the loss of ACC1 expression attenuated AHR (Figure 1D) and the total immune-cell numbers in the lung and the bronchoalveolar lavage fluid (BALF) (Figure 1—figure supplement 1B).