To confirm that ACC1-mediated metabolic programming in iNKT cells regulates the development of AHR, we pretreated WT or ACC1-deficient iNKT cells with palmitate or pioglitazone, adoptively transferred them into Jα18 KO mice, and then subjected the mice to OVA-induced asthma (Figure 6) or HDM-induced asthma (Fig. S4). This evidence concerns the gene ACACA and asthma.