However, based on our experimental results, we believe that iNKT cells more contribute to the regulation of allergic asthma for the following reasons: (i) while the number of iNKT cells was significantly reduced in Cd4-Cre::Acc1fl/fl mice, the number of conventional CD4+ T cells was only slightly reduced, (ii) Cd4-Cre::Acc1fl/fl mice were dramatically decreased in their AHR in α-GalCer-induced allergic asthma model, and (iii) Jα18 KO mice that lack iNKT cells almost completely restore their AHR when adoptively transferred with WT iNKT cells but not ACC1-deficient iNKT cells. This evidence concerns the gene CD4 and allergic asthma.