TREM2 and Parkinson disease: However, after TREM2 was knocked down, the protein levels of NLRP3 inflammasome, IL-1β, GSDMD, and GSDMD-N in the KD + MPTP group were significantly higher than those in the NC + MPTP group, indicating that the reduction of TREM2 expression can lead to increased activation of NLRP3 inflammasome and aggravate pyroptosis in PD mice, thereby aggravating neuroinflammation.