However, after TREM2 was knocked down, the protein levels of NLRP3 inflammasome, IL-1β, GSDMD, and GSDMD-N in the KD + MPTP group were significantly higher than those in the NC + MPTP group, indicating that the reduction of TREM2 expression can lead to increased activation of NLRP3 inflammasome and aggravate pyroptosis in PD mice, thereby aggravating neuroinflammation. The gene discussed is NLRP3; the disease is Parkinson disease.