CASP1 and Parkinson disease: As shown in Fig. 3A–K, the protein expression levels of NLRP3 inflammasome, its activated effector protein cleaved caspase-1, and the downstream key inflammatory factor IL-1β were increased in the NC + MPTP group compared with the control group, indicating that NLRP3 inflammasome is significantly activated in the process of PD, which aggravates neuroinflammation, thereby leading to the damage of dopaminergic neurons.