As shown in Fig. 3A–K, the protein expression levels of NLRP3 inflammasome, its activated effector protein cleaved caspase-1, and the downstream key inflammatory factor IL-1β were increased in the NC + MPTP group compared with the control group, indicating that NLRP3 inflammasome is significantly activated in the process of PD, which aggravates neuroinflammation, thereby leading to the damage of dopaminergic neurons. Here, IL1B is linked to Parkinson disease.