PLAT and deep vein thrombosis: tPA is categorized as a serine protease essential for clot lysis; thus, activation of tPA by thrombolytic agents such as reteplase, alteplase, and tenecteplase is integral in the management of acute ischemic stroke within 3–4 h, myocardial infarction, arterial thrombosis, pulmonary embolism, and deep vein thrombosis [27, 28].