We and others have reported that Asxl1 loss or transgenic expression of a truncated ASXL1 protein in mice (e.g., Asxl1Y588XTg) impairs hematopoietic stem/progenitor cell (HSPC) function and leads to the development of diverse myeloid malignancies (16–21), demonstrating a crucial role of ASXL1 in normal hematopoiesis and its mutation in the pathogenesis of myeloid malignancies. Here, ASXL1 is linked to myeloid neoplasm.