The functional enrichment analysis with 522 dysregulated genes in Asxl1Y588XTg cells revealed that 109 genes were involved in HSC functions, leukemic stem cells (LSCs), and AML pathways, including Meis1, Prdm16, Gata2, and Hoxb5, which are known to be key for HSPC function and leukemogenesis (Supplemental Table 3). Here, HOXB5 is linked to acute myeloid leukemia.