For example, nfvPPA is most commonly a primary tauopathy as seen in progressive supranuclear palsy or corticobasal degeneration [3, 4] and svPPA is in most cases a TDP-43 proteinopathy [5], both reflecting frontotemporal lobar degeneration (FTLD) pathology, whereas lvPPA is usually caused by Alzheimer’s disease (AD) pathology [6]. The gene discussed is TARDBP; the disease is Alzheimer disease.