WT HeLa cells demonstrated not only higher basal p-T269/S272 p62 compared with CDKL5-KO cells, but also a significantly greater induction of T269/S272 p62 phosphorylation after infection with SINV, which correlated with increasing levels of CDKL5 (Figure 7, D and E; compare time = 0). This evidence concerns the gene CDKL5 and infection.