IFNB1 and infection: Tissue cytokine analysis showed that on day 7, interferon-β (IFN-β), critical for host antiviral innate immune response, increased in CDKL5-WT mice, but not in CDKL5-KO mice (Supplemental Figure 9), indicating that an impaired type I IFN response in CDKL5-KO mice later during infection coincides with higher viral replication.