SQSTM1 and infection: We also monitored the level of p62, a well-established selective autophagy receptor and autophagosome substrate (4), during SINV infection and found that p62 levels decreased over time in WT neurons, whereas CDKL5-KO neurons maintained a higher level of p62 after infection, further suggesting a defect in autophagy in the absence of CDKL5 (Figure 2, C and E).