NTRK1 and Anxiety: Higher doses of BNN27 may have two repercussions: (a) activate other receptors with lower affinity compared to TrkA/p75NTR receptors, which might counteract its anti-anxiety effects, and (b) provoke desensitization through internalization of its TrkA/p75NTR receptors and their known long-lasting turnover and their intracellular trapping (Pediaditakis et al. 2016a).